10 Blocking Antibodies
Description
This article is from the Miscarriage FAQ, by Laura Brooks brook006@mc.duke.edu with numerous contributions by others.
10 Blocking Antibodies
One out of every 200 - 300 couples who marry and start a family will share
similar tissue types to their spouse. Basically this is a white blood cell
(WBC) problem. In the WBC system symbols relate to different types of
cells. The last 4 symbols are called the DR / DQ numbers . these DR/DQ
numbers are inherited . Couples who lose every pregnancy are matched for 3
out of 4 of these number (symbols). David and I found out that we are an
"unlucky match". Our DR / DQ numbers are 1.1, 1.2, 1.3 and a 4 . There is
little more than one amino acid's difference between us. This means we are
75% alike.
As you know the WBC system is our defense against disease. Each of the
above numbers within the WBC system have little antennae which when touched
by a certain virus or bacteria sends signals to make antibodies. These
antibodies take care of any foreign interlopers (bacteria) entering the
body. The man has all the genes (in his sperm) to blueprint out the
placenta. He starts to build the placenta . This sends a message from
outside of the woman's body (from the genes within the sperm) to alert the
mother's body to prepare for a baby. The message sent from the man is
called "g". All the cells of the placenta that line up around the egg have
the genes that will be needed to construct the placenta and the message
sent is also "g". The mom and dad are now in a partnership together
building the placenta. The dad's "g" should be different from the mom's
"g". The mom is responsible for making antibodies to dad's "g". This will
provide a camoflage for the baby making it a sort of "wolf in sheep's
clothing". The "g" of the husband acts liks a fertilizer, a growth molecule
telling the placenta to grow and divide. When a couple is similar (as we
are) there are too few antibodies to "cloak" the fetus. The placenta
doesn't grow and divide like it should, beta tests don't double,
ultrasounds may be "up and down" , the sac may disappear and the pregnancy
is pretty much doomed.
There is hope for this problem. Dr. Beer extracts the WBC from the husband
(or a donor if the couple is too similar). The lab takes the WBCs and feeds
them wheatgerm . After a couple of hours of breakfast the cells grow and
divide. Dr. Beer theorizes at this point the "g" comes out of hiding. A
concentrated serum is made (10,000 times stronger than what would be found
in the placenta) and it is injected under the skin of the forearm (of the
wife) much like a skin test for allergies. After two lymphocyte
immuniztions (two sets of injections) the couple ought to be capable of
producing the blocking antibodies necessary to take the pregnancy to term.
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