Calcipotriol and Calcipotriene (Dovonex) Drug for Psoriasis: Use, Side Effects, Interactions

Calcipotriol/Calcipotriene
(Dovonex, United States and Canada; Daivonex, Europe)

Use:

Calcipotriol or Dovonex is used to reduce skin plaque formation in psoriasis.

How It Works:

Calcipotriol or Dovonex is a synthetic vitamin D3 analog, which is able to reduce skin cell proliferation. It appears as effective as corticosteroid creams and ointment, but with fewer side effects - especially those side effects due to skin absorption. Tachyphylaxis or decreased responsiveness to therapy develops with corticosteroids, but not with Calcipotriol or Dovonex.

Side Effects:

Calcipotriol or Dovonex is well tolerated and its side effects are confined to skin irritation - burning, itching, redness, dry skin, peeling, sun sensitivity. With time these side effects seem to moderate.

Cautions for People:

People who have sensitive skin should use Calcipotriol or Dovonex with caution.

Drug Interactions:

Calcipotriol or Dovonex is using in combination with other types of therapy to treat psoriasis. It is often combined with ultra violet therapy.

Further Reading:

J Am Acad Dermatol 1992;27:983
Med Letter 1994;36:70

Added to Virtual Drugstore August 1996.

The relevant product monographs must be regarded as the appropriate sources of prescribing information.